U 89843A ( —— )

Catalog No. M27731 CAS No. 157013-32-6

U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

U 89843A
Note

Research use only, not for human use.
Brief Description

U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.
Description

U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.(In Vitro):In the alpha 1 beta 2 gamma 2 subtype of GABAA receptors expressed in human embryonic kidney cells, U 89843A dose-dependently enhanced 5 microM GABA-induced Cl- currents with a maximal enhancement of 362 +/- 91%, a half-maximal concentration of 2 +/- 0.4 microM and a slope factor of 1.1 +/- 0.4. U 89843A also inhibited [35S]t-butylbicyclophosphorothionate binding in rat cerebrocortical membranes with a similar half-maximal inhibitory concentration.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

acetylcholinesterase
Research Area

——
Indication

——

Chemical Information

CAS Number

157013-32-6
Formula Weight

321.9
Molecular Formula

C16H24ClN5
Purity

>98% (HPLC)
Solubility

——
SMILES

Cl.Cc1cc2c(nc(nc2n1C)N1CCCC1)N1CCCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Dafforn A, et al. Acetylcholinesterase inhibition by the ketone transition state analog phenoxyacetone and 1-halo-3-phenoxy-2-propanones. Biochem Biophys Res Commun. 1982 Jan 29;104(2):597-602.

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